I don't know about you, but I LOVE anime crazy-ass villains!!! It all started with the second season of Digimon. The first time I ever met Ken. Love that guy, whether if he's innocent Ken or Digimon Emperor Ken. Which made me think, a lot of my crazy-ass villain favorites in various series are usually the seme in a yaoi relationship, and in that case, if they were cross-paired (or whatever the term is) with crazy-ass villains from other series, hmmm: (how you go from crazy-ass villains to Digimon Emperor Ken to yaoi, I don't know)

MY favorite
1. Muraki and Akabane (both are scary ass doctors, assuming Akabane's one. And both have some freaky body enhancements-Muraki: eye/Akabane: scalpals-)

Other Parings (not necessarily from different series)
2. Yuki and Tatsuha (I've seen this couple before, Yuki's the uke)

3. Ryuichi and Shuichi (I mean, come on, their names freakin' RHYME)

4.Enishi and Ban (....they have the same hairstyle and glasses [?])

5. Aion and Muraki (Between the two, I can't tell who's the whiter villain)

6. Touya and Yuhi (That would have been a funny couple)

7. Duo and Zechs (I just put them together because they were my fav. characters for the whole series. Another thing is I don't even think they so much as looked at each other the whole entire series so I know, personally, this couple couldn't happen)

8. Duo and Kouga (Same voice actor! Maybe even personality, minus Kagome)

9. Sesshoumaru and Kouga (Inside joke)

10. Yoko and whoever (I heard from a friend of mine that he's basically the whore of the Yu Yu Hakusho series, so him and whoever would work out fine)

11. Yue and Sephiroth (it TOTALLY would work out!! I mean, think about it, they would be the yin to each others' yang. They would be each other's light side and dark side. That couple could TOTALLY work out)

12. Heero and Zechs (It could happen)

Same Series Yaoi Pairings (as the focus point)

1. Yusuke and Kuwabara (I know that's a couple, I just know it)

2. Laguna and Squall (they're both fav. characters, AND I saw this pairing before)

3. Sephiroth and Vincent (I bet it would work out)

4. Zell and Irvine (...I think it would work out)

5. Sessoumaru and Naraku (I KNOW that's a couple)

6.Cloud and Sephiroth (I know that's couple)

7. Tidus and Auron (I mean, think about it, it's possible)

8. Aoshi and Saitoh ( it's possible, maybe)

9. Spike and Vicious (think about it, BEFORE Julia came along...it's possible)

10. Daisuke and Shun (I think Heat Guy J is another series where you can pair people off with their siblings)

On the whole, I would support ANY couple as long as you have some reason for pairing them, and, especially, if it's my fav. character with somebody. I, usually, don't care who my fav. character is paired with. The crazier the couple, the more likely I am to support it!!